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    DIETI Contact person / Partner: Gennaro Bellizzi

    Abstract

    The proposed project aims at the development and the experimental validation of a lowcomplexity microwave imaging device capable of addressing currently unmet clinical needs arising in brain stroke diagnosis and treatment, namely early diagnosis and monitoring in the post-acute stage. The project will be developed within an international intersectoral (academic/medical/enterprise) consortium of partners with a background in electromagnetic engineering, medical sciences and imaging technologies.

    Objectives

    The project aims at improving the effectiveness of brain stroke diagnosis and treatment by introducing an innovative technological solution capable of performing early-stage diagnosis and continuous monitoring at the patient’s bedside.

     

    DIETI Contact person / Partner: Andrea Irace

    Abstract

    The research aims to design and develop small and lightweight sensors for non-invasive, ubiquitous patient monitoring. The continuous acquisition of vital parameters such as cardiac rhythm, respiratory rate, cardiac mechanics, blood pressure in addition to the activity level provides doctors with additional information on the patient's health and may supports more prompt diagnoses and therapies. Sensors wireless connectivity with mobile devices will allow to provide telemedicine applications.

    Objectives

    Design of innovative sensors for continuous patient monitoring. Development of prototype devices easily wearable, low-power and with wireless connectivity. implementation of data analysis and an integrated telemedicine system.

     

    DIETI Contact person / Partner: Carlo Forestiere

    Abstract

    In this activity, the PhD candidate will develop a nanophotonic biosensor aimed at the detection of circulating non-coding RNAs (miRNAs). The sensor will be based on novel anomalous electromagnetic scattering effects emerging at the nanoscale. The PhD candidate will design the electromagnetic properties of the nanophotonic substrate under the guidance of Prof. Forestiere; then he will fabricate and characterize the device under the supervision of Dr. De Stefano. Eventually, he will test the optical sensors under the guidance of Prof. Caraglia, M.D.

    Objectives

    The objective of this proposal is to develop a nanostructured nano-biophotonic able to accurately detect circulating miRNAs, that is at same time cheaper and have limited invasiveness compared to the methods currently used for screening.

     

    DIETI Contact person / Partner: Ettore Napoli

    Abstract

    Recently it has been demonstrated that specific miRNAs can indicate and characterize a haemorrhagic condition of the patient. Unfortunately, the miRNA detection requires many hours nullifying the stroke minimization actions that are needed within five hours in most patients.Electronic sensing through large area CMOS sensors could be able, starting from a biological fluid of the patient, to detect the miRNA generated fluorescence allowing a significant reduction of time, cost, and difficulty of the diagnosis.The research activity focuses on the development of the algorithms, and the design of the related digital circuitry, for measurement of the minute fluorescence generated on large area CMOS sensors.

    Objectives

    The research activity aims at designing a lab on chip based on a large area customized CMOS sensor, surrounding circuitry, and human interface for the detection of the miRNA fluorescence signal.The chip should diagnose the haemorrhagic condition exploiting the photoluminescence signal arising from the specific recognition between complementary nucleotides’ sequences and labelling with fluorescent tags as the transduction principle. The extended sensor’s surface will permit to carry out an efficient data integration and to reduce the electronic noise. Dedicated algorithms will be needed to carry out the challenging task of extracting the limited signal from the noisy environment counteracting chip derating, temperature, and chip to chip variability.

     

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