DIETI Contact person / Partner: Antonia Maria Tulino
Abstract
The goal of this research activity is the development of computational tools and algorithms for diagnostics at the single cell level by using holographic imaging in opto-fluidic environments. Recently, optical imaging and microfluidics was used synergistically to synthesize novel functionalities for biological samples characterization. Among optical imaging modalities, the label-free quantitative phase imaging by digital holography has been demonstrated as one of the most powerful method to investigate biological samples for diagnostic purposes. The digital holography research unit at the Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche (ISASI-CNR), has been recognized as worldwide leader in the aforementioned fields, especially for applications in blood diseases diagnostics.
Objective
The PhD research activity will focus on the development of new algorithms and computational tools for:
- Fast and accurate identification of rare cells in blood samples though suitable label-free biomarkers;
- Speeding up the holographic processing with the aim to implement the real-time point-of-care diagnostics paradigm;
- Design and implementation of new opto-fluidics solutions.
The possibility to employ deep learning based strategies to achieve the proposed goals will be considered
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Available
Can be assigned to one doctoral student of cycle XXXVI